Every quantitative substrate, integrator and pathology modifier in the engine is anchored in peer-reviewed literature. Citations below are normative — deviations from published parameter ranges are flagged in the diagnostic warnings panel.
Reimann M.W., Nolte M., Scolamiero M., et al. · Frontiers in Computational Neuroscience (2017)
Demonstrates that cortical microcircuits contain dense cliques of up to 11 neurons and cavities forming a structural-functional bridge. Substrate for our maximal-clique enumeration on the Schaefer-200 connectome.
Tewarie P., Abeysuriya R., Byrne Á., et al. · NeuroImage 188 (2019)
Establishes algebraic-topology invariants of clique complexes as predictors of resting-state fMRI dynamics. Underpins our use of clique counts as a topological-integrity proxy.
Rodrigues F.A., Peron T.K.DM., Ji P., Kurths J. · Physics Reports 610 (2016)
Comprehensive treatment of finite-N Kuramoto dynamics on heterogeneous networks. Direct reference for our integrator (dθ/dt = ω + K/N · Σ W·sinΔθ + ξ) and order-parameter measurement.
Cabral J., Hugues E., Sporns O., Deco G. · NeuroImage 57 (2011)
Validates Kuramoto coupling on empirical DTI/fMRI connectomes as a generative model of resting-state BOLD dynamics. Justifies our use of R = |⟨e^iθ⟩| as a network-coherence biomarker.
Schaefer A., Kong R., Gordon E.M., et al. · Cerebral Cortex 28 (2018)
Multi-resolution functional atlas. Our baseline topology samples N=200 ROIs assigned to the 7 Yeo networks (Default, Control, Limbic, Visual, SomatoMotor, VentAttn, DorsalAttn).
Kaiser R.H., Andrews-Hanna J.R., Wager T.D., Pizzagalli D.A. · JAMA Psychiatry 72 (2015)
Meta-analysis of 25 fMRI studies confirming sustained DMN hyper-coupling in major depression. Encoded as the `mdd` pathology modifier (intra-DMN edge boost + control-network attenuation).
Akiki T.J., Averill C.L., Abdallah C.G. · Current Psychiatry Reports 19 (2017)
Network-based review documenting amygdala/limbic hyper-arousal and prefrontal-limbic decoupling. Encoded as the `ptsd` modifier (limbic-clique noise injection + control edge sparsification).
Ly C., Greb A.C., Cameron L.P., et al. · Cell Reports 23 (2018)
Cellular evidence for BDNF/TrkB-mediated dendritogenesis driven by serotonergic psychedelics. Foundation for the `repair` vector applied by ZB-01, NX-44, and classic psychedelics.
babelForge is a research-grade in-silico engine. Compound vector magnitudes are derived from receptor-affinity scaling and clinical-dose equivalence; they are not a substitute for prescriber judgement. The ZB/SS/LL/DR/NX series are pipeline candidates and not approved therapeutics.